Rema was born on May 1, 2000 in Benin City, Edo State. He attended primary and secondary school in Edo State. Rema grew up listening to Afrobeat and commercial rap. He formed a rap group with peers from his church.
Rema and his friend Alpha P formed the RnA group in 2013. The name of the band is a mash-up of the first letters of their stage names. RnA won the second season of Pikolo's Dream Alive.
In February 2018, he posted a video of himself freestyling to an instrumental version of D'Prince's "Gucci Gang," which piqued his interest in music. D'Prince saw the video and contacted Rema, which led to his signing with Mavin, Don Jazzy's Lagos-based label.
In 2019, he released his self-titled debut EP "Rema." He released the four-track EPs Rema, Freestyle, and Bad Command, which peaked at number one on Apple Music Nigeria.
He rose to prominence after the release of his song "Iron Man," which was included on Barack Obama's 2019 Summer Playlist.